Membrane Microdomain Signaling Lipid Rafts in Biology and Medicine [Paperback]

Cutting-edge articles review our current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.Cutting-edge articles review our current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.From Intramolecular Asymmetries to Raft Assemblies: A Short Guide for the Puzzled in LipidomicsEphraim Yavin and Annette BrandRegulatory Aspects of Membrane Microdomain (Raft) Dynamics in Live Cells: A Biophysical ApproachJ?nos Matk? and J?nos Sz?llosiLipid Raft Membrane SkeletonsElizabeth J. Luna, Thomas Nebl, Norio Takizawa, and Jessica L. CrowleyRole of Cholesterol in Membrane Microdomain SignalingChristopher J. FieldingRaft Lipid Metabolism in Relation to Alkyl-Lysophospholipid-Induced ApoptosisArnold H. van der Luit, Marcel Verheij, and Wil,