The Merkel Cell Structure-Development-Function-Cancerogenesis [Hardcover]

Since their first description in 1875, Merkel cells have remained an elusive cell type. Their origin as well as their classification as mechanoreceptors have been a matter of controversy and intense discussion. The peptidergic granules in these cells are suggestive of neuroendocrine functions, but their discovery has raised additional questions regarding Merkel cell function.

Essential aspects of structure, development and function of normal Merkel cells and Merkel cell carcinoma are presented in short chapters, providing concise and up-to date information on this fascinating cell type.

Since their first description in 1875, Merkel cells have remained an elusive cell type. Their origin as well as their classification as mechanoreceptors have been a matter of controversy and intense discussion. The peptidergic granules in these cells are suggestive of neuroendocrine functions, but their discovery has raised additional questions regarding Merkel cell function.

Essential aspects of structure, development and function of normal Merkel cells and Merkel cell carcinoma are presented in short chapters, providing concise and up-to date information on this fascinating cell type.

From the contents: Merkel cells as mechanoreceptors in vertebrates.- 3D-microanatomy of Merkel cells.- FM dye staining of living Merkel cells.- Distribution of Merkel cells in normal skin and mucosae in dogs.- Merkel cells in transplanted flaps.- The sensory system of peri-implant tissue - behavior of Merkel cells and nerve fibres.- Merkel cell nerve endings in sinus hairs of young and aged rats.- Immunohistochemical characterization of normal canine Merkel cells.- Merkel cells in the human fetal and adult esophagus.- Possible functional significance of spatial relationship between Merkel cells and Langerhans cells in human hair follicles.- Mammalian Merkel cells as neural crest derivativel£B