Metabolic Profiling Its Role in Biomarker Discovery and Gene Function Analysis [Hardcover]

It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.Contributors. Preface. 1. Introduction; G.G. Harrigan, R. Goodacre. 2. Metabolome and Proteome Profiling for Microbial Characterization; S. Vaidyanathan, R. Goodacre. 3. Can 1H NMR Derived Metabolic Profiles Contribute to Proteomic Analyses? J.L. Griffin, E. Sang. 4. Application of Metabonomics in the Pharmaceutical Industry; A.P. Breau, G.H. Cantor. 5. Metabolic Profiling in Tumors by in Vivo and in Vitro NMR Spectroscopy; Yeun-Li Chung, M. Stubbs, J. Griffiths. 6. Raman Spectroscopy for Whole Organism and Tissue Profils/