This SpringerBrief focuses on clinical nutrition research, particularly on the effects of slowly absorbed carbohydrates on postprandial glucose metabolism in type 2 diabetes. Slowlyabsorbed carbohydrates will cause gradual increases in blood glucose and insulin levels, and may therefore be effective as part of a treatment strategy for glycemic control and reduction of cardiovascular complications in type 2 diabetes.
1. Introduction
1.1. Problem Statement and Aims
1.2. Outline
2. Background and Objectives
2.1. Diabetes Mellitus
2.1.1. Diagnostic Criteria
2.1.2. Classification
2.2. Glucose Homeostasis
2.2.1. Role
2.2.2. Regulatory Factors and Actions
2.2.3. Regulation of Glucose Homeostasis
2.2.3.1. Postabsorptive State
2.2.3.2. Postpr
andial State
2.2.4. Abnormal Glucose Homeostasis in Type 2 Diabetes Mellitus
2.2.4.1. Pathogenesis
2.2.4.2. Metabolic Alterations
2.3. Glycemic Control
2.3.1. Glycemic Goals of Therapy
2.3.2. Low Glycemic Index Diet for Glycemic Control
2.3.3. Isomaltulose
2.3.3.1. Digestion
2.3.3.2. Absorption
2.3.3.3. Metabolism and Excretion
2.3.3.4. Human Studies on Glucose Metabolism
2.3.4. CoAdministrat
ion of Carbohydrate and Protein
2.4. Objectives
3. Methods
3.1. Subjects
3.2. Study Design
3.2.1. Isomaltulose/SucroseClamp Study
3.2.1.1. General Methodology
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