Metal Ion in Stroke [Paperback]

Stroke is a major cause of death and disability in the U.S. and worldwide. A variety of pathophysiologic episodes or cellular medications occur following a stroke, and knowledge of these aftermath events can lead to potential therapeutic strategies that may reverse or attenuate stroke injury. Cellular events that occur following stroke include the excessive releases of excitatory amino acids, alterations in the genomic responses, mitochondrial injury producing reactive oxygen and nitrogen species (ROS), and secondary injury, often in the setting of reperfusion.This book examines cellular events following stroke, offering the first systematic discussion of metal ions, their function as co-factors in cellular and genetic signaling and their consequently important roles in biochemistry ranging from essential to toxic.Preface.- Metal Ions In Stroke Pathophysiology.- Mechanisms Of Calcium Influx Following Stroke.- Mitochondrial Ca²⁺ Dysregulation During Stroke And Cell Death.- Calcium Channel Blockers And Stroke Prevention.- Calcium Dyshomeostasis In Astrocytes After Ischemia.- Calcium Signaling At The Blood-Brain Barrier In Stroke.- Zinc Overload In Stroke.- Intracellular Zinc Liberation: A Trigger For Oxidative Stress Induced Toxicity To Neurons And Neuroglia.- Zinc In Stroke: Time For A New Approach?.- Exploring The Zinc Metallome Of Cultured Cortical Neurons Using Synchroton Radiation X-Ray Fluorescence Microscopy.- Iron Neurotoxicity In Ischemic And Hemorrhagic Stroke.- Implication Of Oxidative Stress And Labile Iron In The Molecular Mechanisms Of Ischemic Stroke.- The Role Of Iron In Brain Following Subarachnoid Hemorrhage.- Iron Chelating Therapy In Stroke.- Iron Chelating Therapy In Stroke.- The Role Of Na⁺/Ca²⁺ Countertransport And Other Na⁺-Entry Routes In The Pathophysiology Of Stroke.- Sodium And Potassium MRI In Cerebral Ischemia.- The Impact Of Extracellullӥ