Microbial DNA and Host Immunity [Paperback]

Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).Part I. IntroductionImmunostimulatory DNA: An OverviewEyal RazHistorical PerspectivesSaburo Yamamoto, Toshiko Yamamoto, and Tohru TokunagaPart II. Receptors and SignalingSignal Transduction Pathways Activated by CpG-DNAHans H?ckerA Novel Toll-Like Receptor that Recognizes Bacterial DNAHiroaki Hemmi and Shizuo AkiraActivation of Innate Immunity by Microbial Nucleic AcidsWen-Ming Chu, Xing Gong, and Tony YoonPhosphorothioate Backbone Modification Changes the Pattern of Responses to CpGKatryn J. Stacey, David P. Sester, Shalin Naik, Tara L. Roberts, Matthew J. Sweet, and David A. HumePart III. Cell ActivationActivation of NK Cell by Immunostimulatory Oligo-DNA in Mouse and HumanSaburo Yamamoto, Toshiko Yamamoto, Tetsuro Kataoka, lCë