Microglia in the Regenerating and Degenerating Central Nervous System [Paperback]

The study of microglial cells has recently gained importance for those researching degeneration and regeneration. Microglia in the regenerating and degenerating CNS supports the assertion that understanding microglial biology could perhaps be pivotal for unraveling the pathogenetic mechanisms that underlie Alzheimer's disease, In addition, microglia are also critical for understanding the sequelae of traumatic brain and spinal cord injury, and for the important post-traumatic repair processes. This book gives an up to date account of the role of microglia in degeneration and regeneration of the nervous system and reviews their cell function and physiology.Over the past decade, the study of microglial cells has gained increasing importance, in particular for those working in the fields of degeneration and regeneration. Microglia in the Regenerating and Degenerating CNS supports the assertion that understanding microglial biology could perhaps be pivotal for unraveling the pathogenetic mechanisms that underlie Alzheimer's disease, currently the most widely studied disorder of the central nervous system. In addition, microglia are also critical for understanding the sequelae of traumatic brain and spinal cord injury, and for the vitally important post-traumatic repair processes. This book gives an up to date account of the role of microglia in degeneration and regeneration of the nervous system and also reviews microglial cell function and physiology. Cellular neurobiologists will find that this is a valuable guide to the importance and role of microglia in the CNS.Foreword * Section I. Microglial Physiology * Physiology and Pathophysiology of Microglial Cell Function by Wolfgang J. Streit * Roles of Microglia in the Developing Visual System by Julio Navascues, Miguel A. Cuadros, Ruth Calvente, Jose L. Marin-Teva * Microglial Ion Channels by Claudia Eder * Calcium Signaling in Microglial Cells by Thomas Muller * Microglia as a Source and Target of Cytokine Activities il3