Midkine From Embryogenesis to Pathogenesis and Therapy [Paperback]

Carl Edward Sagans (1934-1996) one of the famous quotation was Who are we? We find that we live on an insignificant planet of a humdrum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people. From past to date, well-known molecules, enzymes, proteins, lipids and carbohydrates are studied in the pathogenesis of several diseases both as a diagnostic/prognostic biomarker and therapeutic agent. The underlying mechanism of unexplained diseases and failure of therapies are frequently studied with well-known biomarkers, but remain unclear in many cases. As Dr. Sagan said other keys are still waiting to be known in some forgotten corner of a body universe, we find strength to propose that one of them can be the growth factor with cytokine activity named Midkine This book summarizes the extensive up-to-date literature overeview with the lastest work of experts about midkine in a detailed format that conveys its role as both a pathologic factor and therapeutic agent.This book combines an extensive, up-to-date literature overview with reports on the lastest research about midkine. Its detailed format conveys the role of midkine as both a pathologic factor and a therapeutic agent.

PART I:? GENERAL ASPECTS OF MIDKINE

CHAPTER? 1???????? General information on midkine

CHAPTER ?2 ??????? The role of midkine in neural development and patterning

CHAPTER? 3???????? Midkine-? A player in innate immunity

CHAPTER? 4???????? Midkine/p63 axis in regulation of epithelial-mesenchymal transition

CHAPTER ?5??????? Immunochemical methods for the detection of midkine in samples of human origin

CHAPTER ?6??? ??? Circulating midkine in malignant, inflammatory, and infectious diseases: a systematic review

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PART II: MIDKINE AND INFLAMMATION

CHAPTER? 7 ??????? Ml£#