Mitochondria in Pathogenesis [Paperback]

Mitochondria are organelles in each cell outside the nucleus and are the energy source of all cells. As such, they are crucial to the healthy functioning of cells. Recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease, from maternally inherited genetic disorders to metabolism defects, aging, stroke, and neurodegenerative diseases such as Parkinson's, Alzheimer's, and Lou Gehrig's disease. This book brings together top researchers whose work in examining the pathophysiologic processes will lead to new strategies for prevention and treatment.Mitochondria are organelles in each cell outside the nucleus and are the energy source of all cells. As such, they are crucial to the healthy functioning of cells. Recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease, from maternally inherited genetic disorders to metabolism defects, aging, stroke, and neurodegenerative diseases such as Parkinson's, Alzheimer's, and Lou Gehrig's disease. This book brings together top researchers whose work in examining the pathophysiologic processes will lead to new strategies for prevention and treatment.Preface. Acknowledgments. Evaluation of Mitochondrial Function in Living Cells. 1. Flow Cytometric Analysis of Mitochondrial Function; H. Rottenberg. 2. Confocal Microscopy of Mitochondrial Function in Living Cells; J.L. Lemasters, et al. 3. Primary Disorders of Mitochondrial DNA and the Pathophysiology of mtDNA-related Disorders; E.A. Schon, S. DiMauro. 4. Transmission and Segregation of Mammalian Mitochondrial DNA; E.A. Shoubridge. 5. Cardiac Reperfusion Injury: Aging, Lipid Peroxidation, and Mitochondrial Function; L.I. Szweda, et al. Mitochondrial Ion Homeostatis and Necrotic Cell Death. 6. Ca2+-Induced Transition in Mitochondria: A Cellular Catastrophe? R.A. Haworth, D.R. Hunter. 7. Physiology of the Permeability Transition Pore; M. Zoratti, F. Tombola. 8. Control of Mitochondrial lc&