Modern Inhalation Anesthetics [Paperback]

With contributions by numerous expertsSection 1..- Foreword and Commentary.- Section 2..- The Chemistry of Modern Inhalation Anesthetics.- I. Introduction.- II. Halothane.- A. Synthesis.- 1. ICI Process.- 2. Hoechst Process.- 3. Miscellaneous Processes.- 4. Synthesis of Optically Active Halothane.- 5. Synthesis of Isotopically Labeled Halothane.- B. Chemical Reactions of Halothane.- 1. Thermal Decomposition.- 2. Reactions with Metals.- 3. Reaction with Base.- 4. Photochemical Reactions.- 5. Halothane Azeotrope.- III. Methoxyflurane.- A. Synthesis.- B. Synthesis of Isotopically Labeled Methoxyflurane.- C. Chemical Reactions of Methoxyflurane.- 1. Thermal Decomposition.- 2. Reactions with Metals.- 3. Reaction with Bases.- 4. Reaction with Acids.- 5. Photochemical Reactions.- IV. Fluroxene.- A. Synthesis.- 1. Air Reduction Process.- 2. Miscellaneous Processes.- B. Chemical Reactions of Fluroxene.- Fluroxene Azeotropes.- V. Teflurane.- A. Synthesis.- B. Chemical Properties.- 1. Reaction with Base.- 2. Photochemical Stability.- VI. Roflurane.- VII. Flammability.- VIII. Foaming in Halogenated Anesthetics.- References.- Section 3.0 Clinical Monographs.- 3.1 Halothane.- I. Development of Halothane and Early Clinical Trials.- II. Physical and Chemical Properties of Halothane.- III. Methods of Assaying Halothane Concentration.- IV. Methods of Administration: Anesthetic Circuits and Vaporizers.- A. Anesthetic Circuits.- B. Vaporizers.- V. Uptake and Distribution of Halothane  Clinical Considerations.- VI. Anesthetic Requirement of Halothane.- VII. Effects on Physiological Systems.- A. Nervous System.- B. Cerebral Circulation and Metabolism.- C. Respiratory System.- D. Circulatory System.- E. Liver.- F. Other Systems.- VIII. Clinical Considerations.- A. Specific Applications.- B. Miscellaneous After-effects.- IX. Concluding Remarks.- References.- 3.2 Methoxyflurane and Teflurane.- I. Pre-Anesthetic Medication.- II. Techniques of Administration.- A. Open Drop Technique.- B. Semlƒv