Molecular Basis for Therapy of AIDS-Defining Cancers [Hardcover]

Cancer incidences increase in people living with HIV/AIDS. Over 2 million people currently live with HIV/AIDS in the US. This number will increase as HAART prolongs the average lifespan and as (at least in some states) the number of new HIV infections increase again. As this population ages their incidence rates for cancer will increase, as well.

Recently, new rational targets for cancer therapy have emerged. But their application to the care of HIV+ patients is slow, because of concerns about the weakened immune status of the patients, because of possible drug interactions with HAART and because some of the AIDS defining cancer are rare.

Cancer incidences increase in people living with HIV/AIDS. This book provides an update of the latest treatments for AIDS defining cancers. It updates scientific rationale for established treatments and reviews novel molecularly-targeted treatment options.

Cancer incidences increase in people living with HIV/AIDS. Over 2 million people currently live with HIV/AIDS in the US. This number will increase as HAART prolongs the average lifespan and as (at least in some states) the number of new HIV infections increase again. As this population ages their incidence rates for cancer will increase, as well.

Recently, new rational targets for cancer therapy have emerged. But their application to the care of HIV+ patients is slow, because of concerns about the weakened immune status of the patients, because of possible drug interactions with HAART and because some of the AIDS defining cancer are rare.

Foreword -J. Pagano, UNC Linberger Comprehensive Cancer Center Epidemiology of AIDS defining Cancers - D. Whitby, NCI Frederick - J. Martin, UC San Francisco Interferon-alpha therapy for Kaposi sarcoma - Susan E. Krown, Memorial Sloan Kettering Cancer Center Rapamycin and mTOR inhibitors in primary effusion lymphoma and Kaposi sarcoma - B. Damania, UNC LlS%