Molecular Biology of the Arterial Wall [Paperback]

The outstanding contributions to this volume are designed to shed light on some fields of cell biology and cellular pathology, including newly observed phenomena of cell-cell interactions, which might be applicable in studying the pathological process of atherosclerosis. The topics included cover: lipoproteins and lipoprotein receptors; growth factors; endocytosis and exocytosis; ONC Genes and proliferative disease; white blood cells; prostaglandins and leukotrienes; and the biology of smooth muscle and endothelium. The volume provides a complete summary of the most important developments in the field with great impact for arteriosclerosis research.Workshop I Lipoproteins and Lipoprotein Receptors.- LDL Receptor Mutations in Patients with Familial Hypercholesterolemia.- Lipoprotein Receptors and Their Ligands: Structure and Function of Apoproteins E and B.- The Role of HDL in Cholesterol Homeostasis of Macrophages and Reversed Cholesterol Transport.- Lipoproteins, Macrophages and Atherosclerosis.- Arterial Lipoprotein Metabolism: Site-Specific Differences Related to Susceptibility to Atherosclerotic Lesions.- Lipoprotein Disposition by the Liver: A Concerted Action of Various Cell Types.- The Macrophage and Endothelial Cell Scavenger Receptor.- Characterization of the Hepatic Scavenger Receptor.- Workshop II Growth Factors.- The Role of PDGF in Health and Disease.- Role of PDGF-like Growth Factors in Autocrine Stimulation of Cell Growth.- The PDGF Receptor as a Mediator of Mitogenesis.- Alpha-and Beta-Heparin Binding Growth Factors: Chemistry and Biology of Acidic and Basic Fibroblast Growth Factors.- Structure, Homologies and Activities of Acidic Fibroblast Growth Factor.- Endothelial Cell Growth Factor and its Receptor.- Workshop Ill Endocytosis and Exocytosis.- Intracellular Transport of Human Class I Antigens and an Adenoviral Glycoprote?n.- Molecular Mechanisms of Endocytic Sorting.- Characterisation of a Fusion Event from the Endocytic Pathway.- Membrane Boundl£"