Molecular and Cellular Biology of Neuroprotection in the CNS [Paperback]

Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.I: Neuronal Cell Death - Overview of Basic Mechanisms. 1. Excitatory amino acid neurotoxicity; T. Gillessen, et al. 2. Neuronal survival and cell death signaling pathways; R.S. Morrison, et al. 3. Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system; G. Stoll. 4. Cellular and molecular determinants of glial scar formation; A. Logan, M. Berry. II: Ion Channels, Receptors and Signaling Pathways. 5. Na+ channels and Ca2+ channels of the cell membrane as targets of neuroprotective substances; C. Alzheimer. 6. Intracellularl³„