Molecular Chaperones [Paperback]

Currently one of the hottest topics in biochemistry, the concept of molecular chaperones has challenged the paradigm of protein self-assembly. Key figures in many disciplines review all aspects of molecular chaperones in this volume, which arises from a Royal Society discussion meeting. Overview chapters discuss the significance of chaperones in biochemistry, molecular genetics and cell biology. Each chapter is well referenced providing access to the literature.Currently one of the hottest topics in biochemistry, the concept of molecular chaperones has challenged the paradigm of protein self-assembly. Key figures in many disciplines review all aspects of molecular chaperones in this volume, which arises from a Royal Society discussion meeting. Overview chapters discuss the significance of chaperones in biochemistry, molecular genetics and cell biology. Each chapter is well referenced providing access to the literature.Part One: Chaperones for genome replication and expression. Introduction: the molecular chaperone concept - R J Ellis. Neucleoplasmin and modulations of chromatin structure - R A Laskey. Microbial DNA replication - M Zylicz. The control of gene expression - S Lindquist. Part Two: Chaperones for protein folding. Protein in self-assembly - R Jaenicke. Interactions of chaperonins with folding intermediates - G H Lorimer. Chaperonin-mediated protein folding at high temperatures - M Yoshida. Chaperonin-like proteins in archaebacteria - A Horwich. Chaperones and nascent polypeptides - W J Welch. Tumour suppressor gene products as chaperones - D P Lane. Part Three: Chaperones for protein transport. Introduction - A Coleman. Microsomal protein transport - J E Rothman. Transport and assembly processes in the endoplasmic reticulum - M J Gething. Bacterial protein transport S J S Hardy. Mitochondrial protein transport - W Neupert. Part Four: Chaperones and disease. Chaperonins and the immune response - D B Young.lCÔ