Molecular Determinants of Radiation Response [Paperback]

Molecular Determinants of Radiation Response includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins. The chapters include comprehensive discussions on where and how specific alterations in function of these pathways and proteins result in substantive modifications of cellular response to DNA injury. Given the importance of therapies that induce DNA injury in the management of human disease, this book is timely and relevant for basic and translational researchers, as well as clinicians alike.Molecular Determinants of Radiation Response provides an overview of key DNA damage response pathways and proteins. Chapters include discussions of where and how specific alterations in these pathways result in substantive modifications of cellular response to DNA injury.

Molecular Determinants of Radiation Response

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Editors:? Theodore L. DeWeese, M.D. and Marikki Laiho, M.D., Ph.D.

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Molecular Basis of the DNA Damage Responses

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1)?????? H2AX in DNA Damage Response?????????????????????????????????????????????????????????????????????????????????????????????????????

Christophe E. Redon, Jennifer S. Dickey, Asako J. Nakamura, Olga A. Sedelnikova, and William M. Bonner

2)?????? DNA Damage Signaling Downstream of ATM????????????????????????????????????????????????????????????????????????????????????

????????? Fred Bunz

3)?????? Checkpoint Control Following Radiation Exposure????????????????????????????????????????????????????????????????????????????????

????????? Markus Lobrich, Aaron A. Goodarzi, Tom Stiff and Penny A. Jeggo

4)?????? Chromatin Responses to DNA Damage????????????????????????????????????????????????????l£K