The Molecular Genetics of Lung Cancer [Paperback]

Lung cancer is the leading cause of cancer mortality in Western countries. It also provides an archetypal example of how inherited predisposing genetic variants may interact with an environmental influence (smoking) to modulate individual cancer risk.

The Molecular Genetics of Lung Cancer describes how the new techniques, methods and approaches of molecular genetics are being used to unravel the complexities of the mechanisms underlying lung tumorigenesis by analysis at the DNA, RNA and protein levels with potentially important implications for tumour classification, diagnosis, prognosis and treatment as well as providing new insights into how lung tumours arise and how they progress to malignancy.

Lung cancer is the leading cause of cancer mortality in Western countries. It also provides an archetypal example of how inherited predisposing genetic variants may interact with an environmental influence (smoking) to modulate individual cancer risk.

The Molecular Genetics of Lung Cancer describes how the new techniques, methods and approaches of molecular genetics are being used to unravel the complexities of the mechanisms underlying lung tumorigenesis by analysis at the DNA, RNA and protein levels with potentially important implications for tumour classification, diagnosis, prognosis and treatment as well as providing new insights into how lung tumours arise and how they progress to malignancy.

Preface.- Acknowledgements.-Chapter 1 An Introduction to the Molecular Basis of CancerCancer genes: Oncogenes. Tumour suppressor genes. Mutator genes and genetic instability. Cell cycle control genes. Apoptosis regulatory genes. Cancer, signaling and acquired capabilities.- Mutational mechanisms in cancer: Pathological mutations in inherited disease and cancer. Mutational spectra in cancer. Mutation in lung cancer.-Chapter 2 Lung Cancer: Setting the lÓÓ