Molecular Mechanisms of Hormone Action 40. Colloquium, 6.-8. April 1989 [Paperback]

Recent years have seen tremendous progress in the field of hormone action and consequent signal transduction. The 40th Colloquium Mosbach was devoted to the discussion of results concerning the molecular process of hormone action, especially the processes following hormone binding to the corresponding receptors. Structural and functional aspects of steroid hormone receptors as well as ion-channel-coupled and enzyme-linked receptors were treated in detail. Particular interest focussed on the latest results concerning transcriptional control, protein phosphorylation, the role of G-Proteins, oncogene proteins, involvement of phospholipases and the regulation of ion channels.Recent years have seen tremendous progress in the field of hormone action and consequent signal transduction. The 40th Colloquium Mosbach was devoted to the discussion of results concerning the molecular process of hormone action, especially the processes following hormone binding to the corresponding receptors. Structural and functional aspects of steroid hormone receptors as well as ion-channel-coupled and enzyme-linked receptors were treated in detail. Particular interest focussed on the latest results concerning transcriptional control, protein phosphorylation, the role of G-Proteins, oncogene proteins, involvement of phospholipases and the regulation of ion channels.1.- Mode of Action of Steroid Hormones: A Historical Review.- Interaction of Steroid Hormone Receptors with DNA.- Clustered Arrangement and Interaction of Steroid Hormone Receptors with Other Transcription Factors.- Chromatin Template Remodeling and Steroid Receptor Transactivation of MMTV.- Hormone-Dependent Transcriptional Activation by Thyroid Hormone Receptors: Functional Homology with Steroid Hormone Receptors.- Subunit Structure of the Glucocorticoid Receptor.- Modulation of Glucocorticoid Hormone Action by Oncogenes and Peptide Hormones.- Studies on the Regulation of Glycogen and Lipid Metabolism by Insulin and Growth Factorsl“›