Molecular Mechanisms in Legionella Pathogenesis [Paperback]

Legionnaires disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.

This book examines different facets of Legionnaires disease, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses.

From amoeba to macrophages: exploring the molecular mechanisms of Legionella infection in both hosts

Pedro Escoll, Monica Rolando, Laura Gomez-Valero and Carmen Buchrieser

The Legionella pneumophila two-component regulatory systems that participate in the regulation of Icm/Dot effectors

Gil Segal

Facets of small RNA-mediated regulation in Legionella pneumophila

Hana Trigui, Nilmini Mendis, Laam Li, Mariam Saad and Sebastien P. Faucher

Type II secretion and Legionella virulence

Nicholas P. Cianciotto

Effector translocation by the Legionella Icm/Dot type IV secretion system

Jiazhl'