Molecular Mechanisms of Metal Toxicity and Carcinogenesis [Paperback]

These proceedings focus on the latest research in molecular mechanisms of metal-induced toxicity and carcinogenesis. The conference promoted a multidisciplinary investigative approach and included presentations from international experts on state-of-the-art information in this field.

During the last two decades, chemical and cellular studies have contributed enormously to our understanding of metal-induced carcinogenesis, and many hypotheses on the role of metals in pathophysiological processes have been investigated. In addition, new techniques are available to shed light on the mechanism of carcinogenesis in molecular terms. This conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis in September 2000 focused on the latest research in molecular mechanisms of metal-induced toxicity and carcinogenesis. The conference promoted a multidisciplinary investigative approach and included presentations from international experts on state-of-the-art information in this field.Preface; X. Shi, et al. Molecular mechanisms of metal-induced toxicity and carcinogenesis; S. Wang, X. Shi. Cadmium-induced apoptosis and phenotypic changes in mouse thymocytes; S. Dong, et al. Cytotoxicity and transcriptional activation of stress genes in human liver carcinoma cells (HepG2) exposed to cadmium chloride; P.B. Tchounwou, et al. Arsenic-induced NFkappaB transactivation through Erks- and JNKs-dependent pathways in mouse epidermal JB6 cells; C. Huang, et al. Lead-related effects on rat fibroblasts; I. Ivo, et al. In vivo reduction of chromium (VI) and its related free radical generation; K.J. Liu, X. Shi. Atrazine potentiation of arsenic trioxide-induced cytotoxicity and gene expression in human liver carcinoma cells (HepG2); P.B. Tehounwou, et al. Combining Drosophila melanogaster somatic-mutation-recombination and electron-spin-resonance-spectroscopy data to interpret epidemiologic observations on chromium carcinogenicity; A.J. Kal.