Molecular Microbiology of Heavy Metals [Hardcover]

This book covers allocation of metals in cells, metal transporter, storage and metalloregulatory proteins, cellular responses to metal ion stress, transcription of genes involved in metal ion homeostasis, uptake of essential metals, metal efflux and other detoxification mechanisms. The book also discusses metal bioreporters for the nanomolar range of concentration and tools to address the metallome. In addition, coverage details specific metals.

All forms of life depend on a variety of heavy metal ions. Nearly one-third of all gene products require a metal ion for proper folding or function. However, even metals generally regarded as non-poisonous are toxic at higher concentrations, including the essential ones. Thus, sensitive regulation of metal uptake, storage, allocation and detoxification is needed to maintain cellular homeostasis of heavy metal ions.

Molecular Microbiology of Heavy Metals includes chapters on allocation of metals in cells, metal transporter, storage and metalloregulatory proteins, cellular responses to metal ion stress, transcription of genes involved in metal ion homeostasis, uptake of essential metals, metal efflux and other detoxification mechanisms. Also discussed are metal bioreporters for the nanomolar range of concentration and tools to address the metallome. Chapters in the second part cover specific metals such as Fe, Mn, Cu, Ni, Co, Zn and Mo as key nutrient elements and Ag, As, Cd, Hg and Cr as toxic elements.

Molecular Physiology of Metal-Microbe Interactions According to Mechanisms.- Understanding How Cells Allocate Metals.- Metalloregulators: Arbiters of Metal Sufficiency.- Transcriptomic Responses of Bacterial Cells to Sublethal Metal Ion Stress.- Bacterial Transition Metal Homeostasis.- Biosensing of Heavy Metals.- A?Glossary of Microanalytical Tools to Assess the Metallome.- Molecular Physiology of Metal-Microbe Interactions According to Groups.- Acquisition of Iron by BactlÃ.