Molecular Targeting in Oncology [Paperback]

This book presents an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer. It is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice.

In Molecular Targeting in Oncology, authors present an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer and is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice.

The volume is divided into five sections that cover the most important elements of drug development. The first section focuses on approaches using targeted therapies to inhibit cell growth. The second section describes how clinicians are evaluating targeted therapies in specific organ systems. The third section illustrates how various classes of pharmacologic and immunologic agents are developed for individual molecular targets. The fourth section details new drugs that have novel mechanisms of action. The final section looks to the future of targeted therapeutics and includes chapters on appropriate patient selection, use of combination therapy, dealing with tumor cell resistance, and more.

Table of ContentsSection 1 General Strategies for Molecular Targeting in OncologyChapter 1 The Cell Cycle: Therapeutic Targeting of Cell CycleRegulatory Components and Effector Pathways in CancerChad D. Knights and Richard G. PestellChapter 2 mTOR: Properties and TherapeuticsJohn B. Easton and Peter J. HoughtonChapter 3 Ras/Raf/MEK InhibitorsJoseph A. Splƒ/