Monoclonal Antibodies [Paperback]

Monoclonal antibodies have a very important and wide-ranging role in many areas of biomedical research and this volume is amongst the very first to combine technical and clinical aspects of the subject.This book aims to provide a unique combination of the production (by both cellular and molecular biology techniques), structure and functional characteristics of monoclonal antibodies, together with detailed discussions of the various analytic, diagnostic and therapeutic applications.This book aims to provide a unique combination of the production (by both cellular and molecular biology techniques), structure and functional characteristics of monoclonal antibodies, together with detailed discussions of the various analytic, diagnostic and therapeutic applications.This book is among the first to combine technical and clinical aspects of the subject. It aims to provide a unique combination of the production (by both cellular and molecular biology techniques), structure and functional characteristics of monoclonal antibodies, together with detailed discussions of the various analytic, diagnostic and therapeutic applications of these antibodies. Many areas of clinical medicine benefit from this type of study including histopathology, oncology, transplantation, infectious diseases, rheumatology, haematology, and dermatology.1. Introduction; 2. Production of monoclonal antibodies; 3. Antigenantibody interactions: how affinity and kinetics affect assay design and selection procedures; 4. The production and characterisation of synthetic peptide-derived antibodies; 5. Human monoclonal antibodies; 6. Bispecific monoclonal antibodies; 7. The production of antibodies using phage display libraries; 8. Genetic manipulation of monoclonal antibodies; 9. Monoclonal antibodies in diagnostic immunoassays; 10A. Monoclonal antibodies in diagnostic pathology; 10B. In vivo targeting of monoclonal antibodies for immunoscintigraphy and therapy of human malignancies; 11A. Monoclonal antibodiel£²