Multiple System Atrophy [Paperback]

This textbook provides a comprehensive monography on multiple system atrophy (MSA), a rare and fatal neurodegenerative disorder that presents with autonomic failure and either parkinsonism (MSA-P) or cerebellar ataxia (MSA-C).The underlying neuropathology of MSA is characterized by striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA) and unique oligodendroglial cytoplasmic alpha-synuclein inclusions. MSA is therefore classified among the alpha-synucleinopathies such as Parkinson`s disease, pure autonomic failure and dementia with Lewy bodies. Over the last decade there have been important advances in early diagnosis, pathogenesis research and clinical trial activity. The monography will cover the entire spectrum ranging from molecular and genetic work to symptomatic and interventional therapies. The book is written for movement disorder clinicians and basic neuroscientists interested in degenerative movement disorders.This book offers complete coverage on multiple system atrophy (MSA), detailing its onset, progression, diagnoses and therapy. It summarizes important advances in MSA research and describes novel findings in MSA research and its therapies.

1. Historical Review.- 2. Epidemiology.- 3. Neuropathology.- 4. Etiopathogenesis.- 5. Animal Models.- 6. Clinical Presentation.- 7. Clinical diagnostic Criteria.- 8. Natural History.- 9. Investigations.- 10. Tratment.

From the reviews:

This book summarizes what is currently known about multiple system atrophy. & The indented audience is both neurology clinicians and neuroscientists who specialize in degenerative movement disorders, but the book also may serve as an additional source of reference for general neurologists or any physicians involved in the treatment of patients with these disorders. & Since it comprises what is currently known about multiple system atrophy, degenerative movement disorder neurologists and neuroscientists shoulc%