Myeloma Bone Disease [Paperback]

This book presents the forefront in the science and clinical management of myeloma bone disease. Coverage begins with sections on clinical presentation, imaging, and biochemical markers and goes on to discuss radiation, surgical, and medical therapies.1. Clinical presentation of myeloma bone disease (MBD)2. Imaging of myeloma bone disease3. Bone Markers in MBD4. Radiation therapy for MBD5. Surgical treatment (kyphoplasty, vertebroplasty and standard surgery)6. Pathophysiology of MBD7. Osteoclast activation in MBD8. Osteoblast Suppression in MBD9. Animal models of MBD10. Bisphopsphonate treatment of MBD11. Osteonecrosis of the jaw in myeloma12. Novel therapies for MBD (Denosumab, velcade and imids)

From the reviews:

This is a highly specialized book dealing with myeloma bone disease. & The book, authoritative as it is, is likely to be of interest to & physicians and scientists with a specific interest in myeloma. & No other book has dealt with the subject of myeloma bone disease in as much depth and, therefore, this one is unique. (Seema Singhal, Doodys Review Service, February, 2011)

This state-of-the-art book presents the forefront in the science and clinical management of myeloma bone disease.  Assembling the work of the world's premier thought leaders, this book begins with sections on clinical presentation, imaging, and biochemical markers and then goes on to discuss radiation, surgical, and medical therapies.  Specific chapters are devoted to bisphosphonates and novel therapeutic agents, such as RANKL inhibitors, Wnt signaling inhibitors, and IMiDs.  The mechanisms of osteoclast activation and osteoblast suppression in multiple myeloma are also explored.

Myeloma Bone Disease is a valuable resource for medical, surgical, and radiation oncologists and cancer researchers.

Presents state-of-the-art knowledge gleaned from revolutionary clinical trials