Nanomaterial Impacts on Cell Biology and Medicine [Hardcover]

The rapidly developing field of nanomaterials has expanded in many commercial areas. More recent studies have begun to provide a foundation for understanding how nanomaterials influence cells and how they also can serve as methodological tools for studies in medicine and cell biology, including research into stem cells. Recent investigations have shown affects of nanomaterials on specific subcellular structures, such as the actin-based brush border network in cells with an increasing emphasis on the barrier function of epithelial tissues. While other studies have shown involvement of nanoparticles in specific cytoplasmic signal transduction events such as the rise in intracellular free calcium, a signaling event known to regulate many changes in cell architecture and function. In parallel, nanomaterials are increasingly used in medicine for drug delivery, treatment of cancer and an increasing number of new applications. This book investigates these areas and also includes new methods for assessment in cell biology and medicine.

1 Presence in, and release of, nanomaterials from consumer products
?Yu Yang and Paul Westerhoff

2 Nanoparticle aggregation: Principles and modeling
Wen Zhang

3? Influences of nanomaterials on the barrier function of epithelial cells
Shariq Ali and Erik Rytting

4 Engineered nanoparticles induced brush border disruption in a human model of the intestinal epithelium
James J. Faust, Benjamin M. Masserano, Adam H. Mielke, Anup Abraham, and David G. Capco

?5 Nanoparticles: Cellular uptake and cytotoxicity
Isaac? M. Adjei,? Blanka Sharma and Vinod Labhasetwar

6 Atomic force microscopy study of the interaction of DNA and nanoparticles
Kungang LI, Songyan Du, Steven Van Ginkel, and Yongsheng Chen

7 Intracellular signal modulation by nanomaterials
Salik Hussain, Stavroló5