Nanoparticles and the Immune System Safety and Effects [Paperback]

Nanoparticles and the?Immune?System provides a reference text for toxicologists, materials scientists and regulators and covers the key issues of interaction of nanomaterials with the immune system. The book discusses several issues that toxicologists and regulators need to know: identification of endpoints that are relevant for assessing hazard, evaluating impact on immunologically frail populations, and how to evaluate chronic/cumulative effects. In addition, the book addresses the possibility of turning the immunomodulating properties of certain nanomaterials to our advantage for amplifying immune responses in certain diseases or preventive strategies (e.g. vaccination).

• Identifies endpoints relevant for assessing hazardous situations, evaluating the impact on immunologically frail populations and how to gauge chronic/cumulative effects
• Raises the awareness of the importance of knowing the effects of the new nanomaterials on our immune system

1. Introduction. How innate and adaptive immunity work
2. Nanoparticles and innate immunity (recognition, reaction/healing vs. chronic inflammation)
3. Nanoparticles and adaptive immunity (T and B cells, antibodies, antigen presentation, autoimmunity)
4. Nanoparticles and allergy/hypersensitivity
5. Nanoparticles and immunological frailty (risk groups)
6. Nanoparticles in medicine
7. Nanoparticles and environmental immunity
8. Summary. Nanoparticle properties vs. immunological mechanisms
9. Conclusions and outlook

A reference text for toxicologists, materials scientists, and regulators that covers the key issues of interaction of nanomaterials (NM) with the immune system

Diana Boraschi is an immunologist that built her experience both in academic institutions (Italian National Council for Nuclear Energy, Italian l³i