Natural Killer T cells Balancing the Regulation of Tumor Immunity [Paperback]

This book will cover primary roles of NKT cells in immunity to cancer, in both mouse tumor models and cancer patients. There are several chapters describing general aspects of NKT cells.This book reviews what researchers have learned about NKT cells during the last two decades through functional studies in the context of tumor immunology, including clinical trials of NKT cell targeted therapy, which show promise for cancer treatment.

Preface.-??Introduction: Mechanisms of NKT cell-mediated adjuvant activity and function of iPS-derived NKT cells.- Structure and Recognition of Antigens for Invariant NKT Cells.- Invariant NKT cell-based vaccine strategies.- Immune regulation of tumor immunity by NKT cells.- The Regulation of CD1d⁺ and CD1d^- tumors by NKT Cells.- DC-based immunotherapy targeting NKT cells.- Therapeutic Approaches Utilising NKT Cells.- NKT Cells of Cancer Patients & How Models can Inform Therapeutic Plans.- Understanding the role of Natural Killer T (NKT) cells in hematologic malignancies: progress and challenges.- Clinical trials with ?-galactosylceramide (KRN7000) in advanced cancer.- Clinical trials of invariant Natural Killer T cell-based immunotherapy for cancer.- Index.??

From the reviews:

This book is essentially a collection of reviews that introduce the reader to the wonderful world of iNKT cells, and how their powerful adjuvant properties are being utilised by different researchers. & this book is worth reading whether you are a new student in the NKT field and want to learn more or whether you are a clinician with an interest in tumour immunology. (Salah Mansour, Immunology News, November, 2012)

Natural killer T (NKT) cells are CD1d-restricted T cells that respond to lipid, not protein, antigens presented by CD1d, which is a non-classical MHC class I-like molecule.? This relatively small but pivotal T cell population bridges the gap between innatl£*