Neuroendocrine Perspectives [Paperback]

Dopaminergic Regulation of the Intermediate Pituitary.- Anatomy.- Innervation.- Dopaminergic Regulation of Intermediate Lobe Secretion.- Early Studies.- Electrophysiologic Studies.- The Dopamine Receptor and Cyclic AMP.- Dopaminergic Regulation of POMC Gene Expression.- Biosynthetic Studies.- Structure and Regulation of the POMC Gene.- Second and Third Messenger Systems.- Dopaminergic Regulation of Post-Translational Processing.- The Enzymology of POMC Processing.- Endoproteolytic Cleavage.- Carboxypeptidase and Aminopeptidase Proteolysis.- Amidation.- Acetylation.- Heterogeneous Proteolysis.- Dopaminergic Regulation of POMC Processing Enzymes.- Dopaminergic Regulation of Cellular and Subcellular Morphology.- Cellular Heterogeneity.- Cell Proliferation.- Summary and Conclusion.- Corticotropin Releasing Factor (Hormone): Physiological and Clinical Implications.- Corticotropin Releasing Factor and the Stress Response.- Pharmacological, Pharmacokinetic and Hemodynamic Properties of Ovine and Human Corticotropin Releasing Factor in Nonhuman Primates and in Man.- Dose-Response Studies.- Pharmacokinetic Properties.- Side Effects and Peripheral Hemodynamic Effects.- The Ovine CRF Stimulation Test in the Differential Diagnosis of Cushings Syndrome and Adrenal Insufficiency.- Cushings Syndrome.- Peripheral oCRF stimulation test.- Inferior petrosal sinus sampling and CRF stimulation in Cushings syndrome.- CRF stimulation testing after surgical therapy for Cushings disease.- CRF stimulation test in Nelsons syndrome.- Adrenal Insufficiency.- Ovine CRF stimulation testing in differential diagnosis.- Adrenal suppression due to glucocorticoid therapy.- Ovine CRF Stimulation in Patients with Hypercortisolemic Psychiatric States.- Primary Affective Disorder.- Anorexia Nervosa.- Proposed Model of CRF Involvement in Psychopathology.- Summary and Conclusions.- Factors Promoting the Growth and Regeneration of Neuronal Cells.- In Vitro Studies of Neuronotrophic and Neurite Promotingl30