Neuroinflammation and Neurodegeneration [Paperback]

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimers disease, Parkinsons disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

Part 1: Mechanisms of Brain Defense and Neuropathogenesis
Chapter 1: The Blood Brain Barrier
Victor Castro, Michal Toborek

Chapter 2: Immune Cell Trafficking in the Central Nervous System
Beena John, Christopher A. Hunter, Tajie H. Harris
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Chapter 3: General Physiology and Pathophysiology of Microglia
Alexei Verkhratsky, Mami Noda

Chapter 4: Inflammation and the Pathophysiology of Astrocytes in Neurodegenerative Diseases?
Gordon P. Meares, Etty N. Benveniste

Chapter 5: Oxidative stress, neuroinflammation, and neurodegeneration
Hui-Ming Gao, Hui Zhou, Jau-Shyong Hong

Chapter 6: Peripheral Neuroimmune Interactions and Neuropathic Pain
Halina Machelska

Part 2: Neurological Diseases and Inflammation<ló#