An international team of experts critically review the recent progress in basic and applied research in angiogenesis. Their cutting-edge discussion ranges from the stimulation and repression of angiogenesis to the discovery of novel targets and the use angiotherapy in the clinic. They also detail the fundamental concepts in the physiology and pathophysiology of angiogenesis and evaluate the potential of angiotherapy in the management of angiogenic disease, highlighting some of the angiogenics and antiangiogenics both in development and in clinical trials.An international team of experts critically review the recent progress in basic and applied research in angiogenesis. Their cutting-edge discussion ranges from the stimulation and repression of angiogenesis to the discovery of novel targets and the use angiotherapy in the clinic. They also detail the fundamental concepts in the physiology and pathophysiology of angiogenesis and evaluate the potential of angiotherapy in the management of angiogenic disease, highlighting some of the angiogenics and antiangiogenics both in development and in clinical trials.I. ConceptsVasculogenesis and AngiogenesisRobert Auerbach and Wanda AuerbachAngiogenesis-Regulating CytokinesMichael S. Pepper, Stefano J. Mandriota, and Roberto MontesanoThe AngiopoietinsPamela F. JonesRegulation of Vascular Morphogenesis by Extracellular Matrix ProteinsAmy D. Bradshaw and E. Helene SageII. Angiogenesis in Health and DiseaseIntegrin Receptors and the Regulation of AngiogenesisDorothy Rodriguez and Peter C. BrooksVasoactive Peptides in AngiogenesisDavid Andrew Walsh and Tai-Ping D. FanAngiogenesis in Wound Healing and SurgeryWayne A. Morrison, Geraldine M. Mitchell, Jane E. Barker, Tamara Konopka, and Alastair G. StewartAngiogenesis and Vascular Endothelial Growth Factor (VEGF) in ReproductionD. Stephen Charnock-Jones, Yulong He, and Stephen K. SmithRheumatoid Arthritis: A Target for Anti-Angiogenic Therapy?Ewa M. Paleolog and Jadwiga M. MiotlaDiagnl“ó