Nicotinic Acetylcholine Receptor Structure and Function [Paperback]

Proceedings of the NATO Advanced Research Workshop on Mechanism of Action of the Nicotinic Acetylcholine Receptors held on the Island of Santorini, Greece, May 19-23, 1986Content.- I. Molecular Structure.- Three-Dimensional Structure of the Acetylcholine Receptor.- Ultrastructural Analysis of the Native Acetylcholine Receptor.- Probing Acetylcholine Receptors with Monoclonal Antibodies.- Acetylcholine Receptor Conformation Probed by Subunit-Specific Monoclonal Antibodies.- What can we Learn About the Acetylcholine Receptor from Synthetic Peptides?.- II. Biophysical and Biochemical Studies of AChR Topography.- Topography of the Acetylcholine Receptor as Revealed by Fluorescence Energy Transfer.- Infrared Studies of the Acetylcholine Receptor Structure.- Monoclonal Antibodies as Probes of Acetylcholine Receptor Function.- Antigenic Specificity of Monoclonal Antibodies Against Torpedo 93 and Human Acetylcholine Receptor, and Use of these Anti-bodies to Investigate Myasthenia gravis.- Tertiary Structure of the Nicotinic Acetylcholine Receptor Probed by Photolabeling and Protein Chemistry.- A Structural Model of the Ion Channel of the Nicotinic Acetylcholine Receptor.- III. Ligand Binding, Ion Flux Studies and Reconstitution.- A General Treatment of Ligand Binding to the Acetylcholine Receptor.- Lipid-Protein Interactions and Acetylcholine Receptor Function in Reconstituted Membranes.- Regulation of Intercellular Signal Transmission. New Approaches to Chemical Kinetic Measurements on Cell Surfaces.- Hysteresis and Channel Properties of the Acetylcholine Receptor from Torpedo Californica.- IV. Electrophysiological Studies.- States of the Nicotinic Acetylcholine Receptor: Enumeration, Characteristics and Structure.- Function of Mammalian Nicotinic Acetylcholine Receptors.- Single Channel Studies of Acetylcholine Receptors Covalently Alkylated with Acetylcholine.- Effects of Allosteric Ligands on the Gating of Single Channel Currents in BC3H-1 Cells.- On the Role of Trophiclƒ¼