Nicotinic Receptors [Hardcover]

A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets. It includes background information on all subtypes of nicotinic receptors, the most recent information on the distribution throughout the nervous system and discussion of their implications in learning and memory, addiction and neurological and psychiatric disease such as Alzheimer's and Parkinson's. Takes advantage of several recent developments in the fields of optogenetics, viral expression and gene analysis to focus on current knowledge on the functional aspects of nicotinic receptors.

Ch. 1: On the Discovery of the Nicotinic Acetylcholine Receptor Channel
Richard Martindale, Robin A.J. Lester, Ph.D.,

Ch. 2: Molecular Structure and Gating
Steen E. Pedersen, Ph.D

Ch. 3: Molecular Underpinnings of Neuronal Nicotinic Acetylcholine Receptor Expression
Michael D. Scofield, Ph.D., Paul D. Gardner, Ph.D.,

Ch. 4: Presynaptic Nicotinic Receptors: Subtypes and Function
Michael J. Marks, B.S., M.S., Ph.D., Sharon R. Grady, Ph.D. Tristan D. McClure-Begley, Ph.D. Heidi C. ONeill, Ph.D., Cristian A. Zambrano, Ph.D.

Ch. 5: Functional Distribution and Regulation of Neuronal Nicotinic Acetylcholine Receptors in the Mammalian Brain
Jerrel L. Yakel, Ph.D.

Ch. 6: Nicotinic Signaling in Development
Catarina C. Fernandes, Ph.D. Adrian F. Lozada, Ph.D. Darwin K. Berg, Ph.D.

Ch. 7: Presynaptic Nicotinic Acetylcholine Receptors & The Modulation Of Circuit Excitability
Chongbo Zhong, M.D. Ph.D., Gretchen Y. Lopez-Hernandez, Ph.D., David A. Talmage, Ph.D., Lorna W. Role, Ph.D.

Ch. 8: Autonomic Nervous System Transmission
Peter B. Sargent, Ph.D.