Normal and Malignant Liver Cell Growth [Hardcover]

Although cell turnover in normal adult liver is extremely low, hepatic tissue is notorious for its almost infinite capacity to regenerate in cases of viral, toxic or traumatic damage. Hepatocellular carcinoma is one of the most frequent malignancies worldwide and causes more than a million deaths per year. The mechanisms governing normal proliferation and malignant transformation of liver cells are of utmost interest for the understanding of regeneration and hepatocarcinogenesis and for the development of new therapeutic strategies.
Therefore, the International Falk Workshop held in Halle, Germany, on January 29-30 1998, focused on the issues of normal and malignant liver cell growth. Knowledge in this area of research has expanded rapidly during recent years. This book of proceedings summarizes the latest advances both in basic science and clinical research. Stimulating discussion set the basis for the development of new strategies in diagnosis and treatment of hepatocellular carcinoma and for the manipulation of regeneration in cases of acute or chronic loss of functional liver tissue.The Proceedings of the International Falk Workshop on 'Normal and Malignant Liver Cell Growth' held in Halle, Germany, on January 29-30 1998Preface. Section I: Liver Growth and Repair. 1. Overview: Recent Developments in Liver Growth - New Pieces to the Puzzle; D.R. LaBreque. 2. Hepatocyte Growth Factor (HGF) and Liver Regeneration; G.K. Michalopoulos, et al. 3. A Diversity of EGF-Like Ligands and Receptors in Liver; W.E. Russell, R.S. Carver. 4. Cytokine Regulation of Liver Regeneration; A.M. Diehl. 5. Initiation of Liver Regeneration by Tumor Necrosis Factor; El¯