Novel Inhibitors of Leukotrienes [Paperback]

Many new antileukotriene drugs are now marketed as antiasthma drugs andrepresent the first new drugs in this field since the 1970s. This bookcovers the steps that have led to the discovery and development of thesenew drugs and offers detailed descriptions of their clinicalapplications. The review chapters on the main aspects of basic andapplied leukotriene research are written by leading specialists in thefield, and the volume takes a new approach in presenting information ofparticular interest to both scientists and clinicians in the fields ofasthma, inflammation and allergic diseases.Many new antileukotriene drugs are now marketed as antiasthma drugs andrepresent the first new drugs in this field since the 1970s. This bookcovers the steps that have led to the discovery and development of thesenew drugs and offers detailed descriptions of their clinicalapplications. The review chapters on the main aspects of basic andapplied leukotriene research are written by leading specialists in thefield, and the volume takes a new approach in presenting information ofparticular interest to both scientists and clinicians in the fields ofasthma, inflammation and allergic diseases.5-Lipoxygenase.- LTC4 synthase: A key enzyme in cysteinyl leukotriene formation.- Leukotriene A4 hydrolase: A key enzyme in chemotactic leukotriene formation.- Metabolism of leukotrienes and formation of new leukotriene structures.- Receptors for cysteinyl-leukotrienes: Targets for new drugs.- Targeted disruption of 5-lipoxygenase.- Transcellular biosynthesis of leukotrienes: A unique mode of cell communication.- Physiological and pathophysiological activities of leukotrienes.- Entry rate and metabolic handling of LTC4 in the human circulation.- Genetic polymorphisms of 5-LO.- Leukotrienes and aspirin-intolerant asthma.- Leukotrienes in nocturnal asthma.- Leukotrienes and allergic asthma.- Inhibitors of leukotrienes: An overview.- The development of zafirlukast (Accolate?) and the Zeneca series of peptil-