Orexin and Sleep Molecular, Functional and Clinical Aspects [Hardcover]

This volume is intended for neuropharmacologists, psychopharmacologists, pharmacologists, pharmacists, sleep researchers, translational neuroscience researchers, and other?basic researchers and clinical scientists interested in an interdisciplinary approach to sleep medicine. The level of the book is aiming at CNS researchers, drug development scientists, basic and clinical sleep researchers, as well as senior medical students and fellows in psychiatry and neurology. Orexin and Sleep provides a unique resource, giving a comprehensive and highly readable summary of the basic concepts in orexin biology and pharmacology along with clinical applications in sleep medicine in general, and narcolepsy in particular.

History of Orexin Research.- The Hypocretin Story.- Input and output systems of orexin neurons.- Physiological roles of orexin receptors on sleep/wakefulness regulation.- Orexin receptor functions in the ascending arousal system?(Folder name - Leonard).- Elucidation of neuronal circuitry involved in the regulation of sleep/wakefulness?using optogenetics?(Folder name - Yamanaka).- Modulation of thalamocortical pathways by orexins.- Orexins, Alcohol and Sleep Homeostasis.- Orexin induced modulation of REM sleep and its loss associated patho-physiological changes are mediated through locus coeruleus.- Role of orexin on sleep: interactions with other neurotransmitter systems.

This is an up-to-date look at these hypothalamicneuropeptides and how we have come to understand their wide range ofneuroregulatory roles. & This is highly technical book that reviews in detailthe research that has led to the discovery and understanding of the orexinneuropeptides and their role in a wide range of neuromodulatory systems. &provide some insights into how manipulation of this system may result intherapeutic interventions for a number of neurological and psychiatricconditions. (Michael Easton, Doodys Book Reviews, February, 2016)