Part I. HistoryHistory and Overview of Orexin/Hypocretin Research: From Orphan GPCR to Integrative PhysiologyMichihiro Mieda and Takeshi SakuraiPart II. Overview of the Orexin/Hypocretin Neuronal SystemOrexin and Orexin ReceptorsTakeshi SakuraiOrexin Projections and Localization of Orexin ReceptorsJacob N. Marcus and Joel K. ElmquistNeuronal Responses to Hypocretin/OrexinAnthony N. van den Pol and Claudio Acuna-GoycoleaAfferent System of Orexin NeuronsAkihiro YamanakaPart III. Assessment of Orexin/Hypocretin Functions in Tissue and Biological FluidsHypocretin Measurements in the CSF, and Blood and Brain Tissue: Basic and Clinical ApplicationsSeiji NishinoHypocretin Receptor-Activated G Proteins Revealed by [35S]GTPgS AutoradiographyRen? Bernard, Ralph Lydic, and Helen A. BaghdoyanPart IV. PhysiologyA. Orexin/Hypocretin System and Hypothalamic FunctionOrexin System and Feeding BehaviorTakeshi SakuraiOrexins and the Autonomic Nervous SystemTetsuro Shirasaka and Masamitsu NakazatoNeuroendocrine Role of the Orexins (Hypocretins)Shahrad TaheriThe Orexin/Hypocretin System and Stress and EmotionYoichi Ueta and Hiroaki FujiharaB. Orexins/Hypocretins and Sleep RegulationHypocretin as a Wakefulness Regulatory PeptideLuis de Lecea and J. Gregor SutcliffeHypocretin/Orexin Tonus and Vigilance ControlYasushi Yoshida and Seiji NishinoHypocretin System and Aminergic and Cholinergic Systems in the Control of VigilanceKrister S. Eriksson and Helmut L. HaasOrexin and Hypothalamic Control of Sleep and WakingRodrigo A. Espa?a and Thomas E. ScammellHypocretin/Orexin and Motor FunctionJerome M. SiegelPart V. Pathophysiology:Narcolepsy and Orexin/Hypocretin DeficiencyA. Orexin/Hypocretin Deficiency and NarcolepsyOverview of Human NarcolepsyScott Fromherz and Emmanuel MignotCanine Models of NarcolepsySeiji NishinoRodent Models of Human Narcolepsy-CataplexyMichihiro Mieda and Masashi YanagisawaB. Orexin/Hypocretin Deficiency in Human Narcolepsy and Other ConditionsHypocretin Deficiency in Hulă-
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