The Parvoviruses [Paperback]

1 Adeno-Associated Virus DNA Structure and Replication.- I. AAV DNA Structure.- II. Replication of AAV.- A. Productive DNA Replication.- B. Abortive DNA Replication.- C. Replication in the Absence of Helper Functions.- D. Replication of Cloned AAV DNA.- III. A Model for AAV DNA Replication.- IV. Host and Viral Proteins Required for AAV DNA Replication.- V. Conclusion.- References.- 2 Biology of Adeno-Associated Virus.- I. Introduction.- II. Association with Adenovirus.- III. Host Range.- IV. Experimental Infection in Utero.- V. Latent Infection.- A. Latent Infection in Vivo.- B. Latent Infection in Vitro.- C. Rescue of AAV DNA Cloned in pBR322.- D. Outstanding Questions.- VI. Inhibition of Adenovirus Oncogenicity.- A. Adenovirus Oncogenicity.- B. Inhibition in Vivo.- C Inhibition of Cellular Transformation.- D. Significance.- VII. Interactions with Herpesviruses.- A. Complementation of AAV by Herpesvirus.- B. Herpesvirus Oncogenicity and AAV.- References.- 3 Adeno-Associated Virus Defectiveness and the Nature of the Adenovirus Helper Function.- I. Introduction.- II. Biological Background.- III. Definition of the Helper Function.- IV. Genome Structure and Growth Cycle of AAV.- A. AAV Genome Structure.- B. Kinetics of Macromolecular Synthesis.- C. Biochemistry of AAV Replication.- D. Possible Sites of Action of Helper Functions in the AAV Growth Cycle.- V. Genome Structure and Growth Cycle of Adenovirus.- VI. Role of Specific Adenovirus Genes in AAV Helper Function.- A. AAV Helper Function of Adenovirus Mutants.- B. Analysis of Helper Function by Microinjection or Transfection of Adenovirus DNA or RNA.- C. Helper Function Involvement of Specific Adenovirus Early Gene Regions.- VII. Growth of AAV in Transformed Cells and Inhibition of Adenovirus Functions.- VIII. Summary.- References.- 4 Autonomous Parvovirus DNA Structure and Replication.- I. DNA Structure.- A. Virion DNA.- B. Replicative Forms.- C. Defective Genomes.- II. DNA Replication.- A. In Vivo Replication.- B.l³t