Peptide Nucleic Acids Methods and Protocols [Paperback]

Exemplifying and illustrating recent exciting advances in PNA chemistry, the second edition of Peptide Nucleic Acids: Methods and Protocols serves as a vital complement to the first edition of the book. Since the discovery of peptide nucleic acids, many interesting new derivatives and analogues in terms of nucleic acid recognition specificity and affinity have emerged. Also, as this detailed volume presents, great ingenuity in exploiting the unique properties of PNAs for a wide variety of applications within drug discovery, medical diagnostics, chemical biology and nanotechnology has unfolded. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

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Peptide Nucleic Acids: Methods and Protocols, Second Edition?serves as a source of useful specific methods and protocols as well as a source of inspiration for future developments.

1. MiniPEG-gPNA

Arunava Manna, Srinivas Rapireddy, Raman Bahal, and Danith H. Ly

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2. Cyclopentane Peptide Nucleic Acids

Ethan A. Englund, Ning Zhang, Daniel H. Appella

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3. Chiral PNAs with Constrained Open-chain Backbones

Roberto Corradini, Tullia Tedeschi, Stefano Sforza and Rosangela Marchelli

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4. Synthesis, Characterization and Evaluation of Radiometal-Containing Peptide Nucleic Acids

Holger StephlÃ#