Pharmaceutical Amorphous Solid Dispersions [Hardcover]

Providing a roadmap from early to late stages of drug development, this book overviews amorphous solid dispersion technology – a leading platform to deliver poorly water soluble drugs, a major hurdle in today’s pharmaceutical industry.

• Helps readers understand amorphous solid dispersions and apply techniques to particular pharmaceutical systems
• Covers physical and chemical properties, screening, scale-up, formulation, drug product manufacture, intellectual property, and regulatory considerations
• Has an appendix with structure and property information for polymers commonly used in drug development and with marketed drugs developed using the amorphous sold dispersion approach
• Addresses global regulatory issues including USA regulations, ICH guidelines, and patent concerns around the worldContents

Contributors

Preface

Chapter 1: Introduction to Amorphous Solid Dispersions
George Zografi and Ann Newman

Chapter 2: Polymers and Surfactants
Padma Narayan, William W. Porter III, Meinolf Brackhagen, and Christopher Tucker

Chapter 3: Amorphous Solid Dispersion Screening
Ann Newman

Chapter 4: Solid state Characterization of Amorphous Dispersions
Frederick G. Vogt

Chapter 5: Physical Stability and Crystallization Inhibition
Lynne S. Taylor

Chapter 6: Solubility and Dissolution Considerations for Amorphous Solid Dispersions
Grace A. Ilevbare, Wei Xuli