Since 1975, the Oklahoma Notes have been among the most widely used reviews for medical students preparing for Step 1 of the United States Medical Licensing Examination. Completely revised and updated, these new editions of the Notes feature: More self- assessment questions, geared to the current USMLE format; more tables and figures to promote rapid self-assessment and review; low prices; and coverage of just the information needed to ensure Boards success.Since 1975, the Oklahoma Notes have been among the most widely used reviews for medical students preparing for Step 1 of the United States Medical Licensing Examination. Completely revised and updated, these new editions of the Notes feature: More self- assessment questions, geared to the current USMLE format; more tables and figures to promote rapid self-assessment and review; low prices; and coverage of just the information needed to ensure Boards success.1 General Principles.- Mechanisms of Drug Action.- Absorption of Drugs.- Distribution of Drugs.- Excretion of Drugs.- Determinants of Plasma Concentrations and Dosage Schedules.- Metabolism of Drugs.- Pharmacogenetics.- Review Questions.- 2 Drugs Acting on the Peripheral Nervous System.- Autonomic Nervous System: Parasympathetic Division (Cholinergic).- Autonomic Nervous System: Ganglia.- Somatic Nervous System: Neuromuscular Blocking Drugs.- Autonomic Nervous System: Sympathetic Division (Adrenergic).- Review Questions.- 3 Drugs Acting on the Kidney.- Diuretics.- Antidiuretic Drugs.- Review Questions.- 4 Drugs Acting on the Cardiovascular System.- Calcium Entry Blockers.- Antianginal Drugs.- Antiarrhythmic Drugs.- Therapy of Congestive Heart Failure.- Therapy of Hyperlipoproteinemias.- Antihypertensive Therapy.- Review Questions.- 5 Drugs Affecting Hemostasis and Hematopoiesis.- Drugs Which Affect Blood Coagulation.- Anti-anemia Drugs (Hematinics).- Review Questions.- 6 Drugs Acting on the Central Nervous System.- Anesthesic Agents.- General Anesthetics.- LoclC,