Pituitary Adenylate Cyclase Activating Polypeptide PACAP [Hardcover]

The first comprehensive book to cover all aspects of the last 25 years of PACAP (pituitary adenylate cyclase activating polypeptide) research, this book contains contributions from virtually all the leading researchers in the field, and addresses some of the following topics: evolutionary aspects of PACAP, distribution and occurrence of PACAP and its receptors, hormonal effects of PACAP, intracellular signaling, effects on cellular proliferation and differentiation, protective effects of PACAP, behavioral effects of PACAP, developmental aspects of PACAP, other physiological effects of PACAP (cardiovascular, thermoregulatory), human studies, drug design, metabolism and transport. This compendium can serve as an important reference for researchers and students in PACAP research and can also be a thorough introduction for those in related fields.Part 1. Evolutionary Aspects of PACAP.- 1. Molecular evolution of Pituitary adenylyl cyclase-activating polypeptide subfamily and cognate receptor subfamily.- 2. Occurrence, distribution and physiological function of pituitary adenylyl cyclase-activating polypeptide in invertebrates species.- 3. PACAP-like compounds of earthworms: identification and putative functions from embryonic development to brain regeneration.- 4. PACAP and learning in invertebrates.- Part 2. Effects of PACAP in Neuronal Development.- 5. PACAP and Neural Progenitor cells.- 6. PACAP and neural development.- 7. PACAP modulates distinct neuronal components to induce cell-specific plasticity at central and autonomic synapses.- Part 3. PACAP Receptors and Signalling.- 8. The pharmacophoric determinants of PACAP.- 9. PACAP-derived carriers: mechanisms and applications.- 10. Effects and development of TAT-tagged PACAP/VIP and related peptides.- Part 4. Presence and Physiological Functions of PACAP in Diverse Systems.- 11. Presence and role of PACAP in endocrine glands of mammals.- 12.Distribution of PACAP in the mammalian nervous system.- 13. Multiple mechanisml;