Principles and Treatment of Lipoprotein Disorders [Paperback]

Atherosclerosis still affects over 50 % of the population in the highly industrialized countries. This book is an update of the treatment of hyperlipidemia, necessary due to the identification in recent years of molecular mechanisms of atherogenesis. Emphasis is on the disease etiology of arteriosclerosis, the treatment of associated or causing diseases and treatment by dietary means or hypolipidemic drugs.Major advances have been made in the understanding of the molecular mechanisms of atherosclerosis, the disease that still affects more than 50 percent of the population in the highly industrialized countries. This volume covers the most recent advances in the treatment of hyperlipidemia. It represents a necessary update because molecular mechanisms of atherogenesis have been discovered in the past few years and their molecular mechanisms of action identified. Extensively treated are the molecular mechanisms of disease etiology of arteriosclerosis in relation to the major risk factor hyperlipidemia , rationale for more effective treatment of this disease by dietary means, the treatment of associated or causing diseases, and the treatment using hypolipidemic drugs.Section A: Physiology and Pathophysiology of Lipid Metabolism.- 1 An Introduction to the Biochemistry and Biology of Blood Lipids and Lipoproteins.- A. Introduction.- B. Blood Lipid Transport: Historical Aspects.- C. Blood Lipids, Apolipoproteins, and Lipoproteins.- I. Lipids.- II. Apolipoproteins.- III. Lipoproteins.- D. Enzymes and Transfer Factors Involved in the Biochemistry of Blood Lipid Regulation.- E. Lipoprotein Metabolism.- I. Transport of Exogenous Lipids.- II. Transport of Endogenous Lipids.- F. Cholesterol and Atherosclerosis.- G. High-Density Lipoprotein Cholesterol and Reverse Cholesterol Transport.- H. Triglycerides, High-Density Lipoprotein Cholesterol, and Coronary Artery Disease.- I. Conclusion.- References.- 2 Lipoprotein Metabolism.- A. Introduction.- B. Plasma Apolipoproteins.- C. Cel#d