Prions and Diseases Volume 1, Physiology and Pathophysiology [Paperback]

Volume I highlights the association of the cellular prion protein (PrP^C) with copper and zinc, the potential roles of PrP^C in Alzheimers disease and cancers, insoluble PrP^C, PMCA, molecular and cellular mechanisms of PrP^Sc formation and clearance, possible co-factors involved in the conversion of PrP^C into PrP^Sc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.Volume I highlights the association of cellular prion protein (PrPC) with copper and zinc; potential roles of PrPC in Alzheimers disease and cancers, infectious and pathogenic forms of PrP, yeast prions and their inheritable and structural traits and more.

Chapter 1??? Transmissible Spongiform Encephalopathy: from the High Middle Ages to Daniel Carlton Gajdusek
Paul Brown

Chapter 2??? The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein
Glenn L. Millhauser

Chapter 3??? Role of Cellular Prion Protein in the Amyloid-? Oligomer Pathophysiology of Alzheimers Disease
Adam C. Kaufman, Stephen M. Strittmatter

Chapter 4??? Cellular Prion Protein and Cancers
Wei Xin, Man-sun Sy, Chaoyang Li

Chapter 5??? Insoluble Cellular Prion Protein
Wen-Quan Zou

Chapter 6??? Protein Misfolding Cyclic Amplification
Fabio Moda, Sandra Pritzkow, Claudio Soto

Chapter 7??? Cofactor Involvement in Prion Propagation
Surachai Supattapone, Michael B. Miller

Chapter 8??? Prion Protein Conversion and Lipids
Jiyan Ma

Chapter 9??? New PerspeclC