Progress in Molecular and Subcellular Biology [Paperback]

Biological functions are almost exclusively attributed to macromolecules, i.e. nucleic acids, proteins and polysaccharides. To gain their complete functional activities these biomolecules have to associate with the nuclear matrix, the cytoskeleton and the cell/plasma membranes. It is the aim of this series to discuss actual aspects in the field of structure-associated genetic and epigenetic functional processes. This series of survey reviews fills the gap in structure-associated information flow, and is a vital reference work for scientists in molecular and cell biology.Biological functions are almost exclusively attributed to macromolecules, i.e. nucleic acids, proteins and polysaccharides. To gain their complete functional activities these biomolecules have to associate with the nuclear matrix, the cytoskeleton and the cell/plasma membranes. It is the aim of this series to discuss actual aspects in the field of structure-associated genetic and epigenetic functional processes. This series of survey reviews fills the gap in structure-associated information flow, and is a vital reference work for scientists in molecular and cell biology.Association of DNA with Nuclear Matrix.- A. Introduction.- B. MAR Elements and Their Properties.- C. Roles of MAR Elements in DNA Packaging and DNA Replication.- References.- Nuclear Import in Vitro.- A. Overview of Nuclear Import.- I. Nuclear Import Occurs Through the Nuclear Pore.- II. The Structure and Composition of the Nuclear Pore.- III. Functional Properties of the Nuclear Pore.- IV. Signals for Nuclear Accumulation.- V. The Effect of Multiple Nuclear Targeting Signals in a Protein.- VI. Is There a Role for Intranuclear Binding in Nuclear Import?.- VII. Nuclear Import is an Active Process. Evidence for a Signal Sequence Receptor.- VIII. Is the Signal Sequence Receptor Heterogeneous?.- IX. Regulation of Nuclear Import.- 1. Changes in Nuclear/Cytoplasmic Localization During Embryogenesis.- 2. Nuclear Import of snRNP Particles.- 3l3#