PTSD Brain Mechanisms and Clinical Implications [Hardcover]

This book breaks new ground by offering neuroscientific insights into post-traumatic stress disorder (PTSD). PTSD has emerged as the model mental disorder for studying the effect of the environment on human biological systems, especially the brain. The authors  who range from skilled basic scientists to experienced diagnosticians and therapists  are leaders in the recent surge of biological investigation into this distressing and disabling condition.

Recent catastrophic events, such as the attack on the New York World Trade Center and the devastating tsunami in the Indian Ocean, have drawn increasing attention to post-traumatic stress disorder, or PTSD. Once thought of only in psychological terms, PTSD has emerged as the model mental disorder for studying the effect of the environment on human biological systems, especially the brain. This book breaks new ground by offering neuroscientific insights into PTSD and their implications for diagnosis, prevention, and treatment. The recent explosion of biological investigation into this distressing and disabling condition has been led by this volumes authors, who range from skilled basic scientists to experienced diagnosticians and therapists. Their contributions epitomize state-of-the-art, translational research in clinical neuroscience, and will prove to be an invaluable source of reference for practitioners and researchers in this field.

Part I Basic Mechanism of PTSD and Stress-Related Brain Dysfunctions Neuroanatomical and Molecular Changes in Stress Responses During Early Life: Implications for Stress Disorders Toru Nishikawa, Akeo Kurumaji, Takashi Ito, Asami Umino, and Sumikazu Ishii Cortisol and PTSD: Animal Experiments and Clinical Perspectives E. Ronald de Kloet and Melly S. Oitzl Stress and Corticosteroid Receptors Mitsuhiro Kawata, Mayumi Nishi, Ken-ichi Matsuda, Hirotaka Sakamoto, Cui Honghai, and Takanori Yoshii Stress Vulnerability Induced by Neonatal Isolation and thelÃ<