The Pyrimidines [Hardcover]

The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

Chapter I. Introduction to the Pyrimidines 1

1. History 1

2. Nomenclature 3

3. The Unique Basis of Pyrimidine Chemistry 5

4. General Summary of Pyrimidine Chemistry 9

5. Physical Properties of Pyrimidines 26

Chapter II. The Principal Synthetic Method 31

1. General Scope 31

2. Use of β –Dialdehydes 32

3. Use of β-Aldehydo Ketones 34

4. Use of β Diketones 36

5. Use of β-Aldehydo Esters 38

6. Use of β-Keto Esters 48

7. Use of β-Diesters (Malonic Esters) 51

8. Use of β-Aldehydo Nitriles 59

9. Use of β -Keto Nitriles 65

10. Use of β -Ester Nitriles

11. Use of β -Dinitriles (Malononitriles)

Chapter III. Other Methods of Primary Synthesis 82

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