Over the last two decades advances in genotyping technology, and the development of quantitative genetic analytical techniques have made it possible to dissect complex traits and link quantitative variation in traits to allelic variation on chromosomes or quantitative trait loci (QTLs). In Quantitative Trait Loci (QTLs):Methods and Protocols, expert researchers in the field detail methods and techniques that focus on specific components of the entire process of quantitative train loci experiments. These include methods and techniques for the mapping populations, identifying quantitative trait loci, extending the power of quantitative trait locus analysis, and case studies. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.
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Thorough and intuitive, Quantitative Trait Loci (QTLs):Methods and Protocols aids scientists in the further study of the links between phenotypic and genotypic variation in fields from medicine to agriculture, from molecular biology to evolution to ecology.
This Methods in Molecular Biology volume offers techniques for the entire process of quantitative train loci experiments: the mapping populations, identifying quantitative trait loci, extending the power of quantitative trait locus analysis and case studies.
Part I. Setting Up Mapping Populations
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1. Backcross Populations and Near Isogenic Lines
Rik Kooke, Erik Wijnker and Joost. J.B. Keurentjes
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2. F2 Designs for QTL Analysis
Yuan-Ming Zhang
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3. Design and Construction of Recombinant Inbred Lines
Daniel lƒ"
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