Reelin Glycoprotein Structure, Biology and Roles in Health and Disease [Paperback]

Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism. The book provides an unprecedented analysis of this emerging and novel protein by examining evidence from genetic, neuroanatomic, biochemical, and behavioral studies.

Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and reelin signaling impairment in brain. Reelin abnormalities in several neurospychiatric disorders, such as autism, schizophrenia, mood disorders and lissencephaly, may provide mechanistic explanations for etiologies of these disorders. There is also emerging data indicating the feasibility of using various medications (valproic acid, olanzapine) to increase mRNA/protein levels for reelin and/or gene therapy to prevent or treat reelin deficiencies observed in the above-mentioned disorders.

This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism.

The Reelin Gene and Its Functions in Brain DevelopmentCheng-Chiu Huang, MSGabriella DArcangelo, PhD*Apolipoprotein E Receptor 2 and Very Low Density Lipoprotein Receptor: An OverviewDr. Hans H. Bock*Prof. Dr. Joachim HerzChemistry of ReelinYves Jossin, PhD*The C-terminal region of Reelin: structure and functionMitsuharu Hattori, PhD*Crystal Structure of Reelin RepeatsJunichi Takagi, PhD*Comparative Anatomy and Evolutionary Roles of ReelinGundela Meyer, MD, PhD*Reelin / Dab1 Signaling in the Developing Cerebral CortexEric C. Olson, PhD*Christopher A. Walsh, MD, PhDUltrastructural Localization of ReelinRosalinda C. Roberts, PhD*Emma Perez-l“t