Regulation of microRNAs [Hardcover]

Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.1. microRNA BIOGENESIS AND FUNCTION - AN OVERVIEW Ren? F. Ketting Abstract Introduction: PTGS in Plants and Small RNAs RNAi Dicer Argonaute The First microRNAs and Links to RNAi miRNAs: Ancient Mediators of Gene Regulation Primary miRNA Processing by Drosha Small RNA Selectivity of Argonaute Proteins Target Recognition Mechanisms of miRNA?Mediated Silencing Regulating miRNAs Conclusion 2. REGULATION OF pri?miRNA PROCESING THROUGH Smads Akiko Hata and Brandi N. Davis Abstract Introduction: Basic Tgf? Signaling miRNA Biogenesis The First Processing Step by Drosha R?Smads Regulate miRNA Maturation Mechanism of Regulation of Specific pri?miRNAs by Smad Transcriptional RegulatiolS9