Restoration of Brain Function by Tissue Transplantation [Paperback]

Cell transplantation to the brain and spinal cord is awell-established research tool for studies on cellular andmolecular mechanisms, but can it be developed into a usefultherapuetic approach in human neurological disorders?Clinical trials in patients with Parkinson's disease haveprovided encouraging evidence, however, no treatment basedon transplantation is available yet. An overview of currentresearch is given in this book. It summarizes the status ofgrafting in humans and discusses scientific problems thathave to be solved before intracerebral transplantation canbecome a useful routine approach to treatment.Cell transplantation to the brain and spinal cord is awell-established research tool for studies on cellular andmolecular mechanisms, but can it be developed into a usefultherapuetic approach in human neurological disorders?Clinical trials in patients with Parkinson's disease haveprovided encouraging evidence, however, no treatment basedon transplantation is available yet. An overview of currentresearch is given in this book. It summarizes the status ofgrafting in humans and discusses scientific problems thathave to be solved before intracerebral transplantation canbecome a useful routine approach to treatment.References.- Transplantation in Parkinsons Disease.- Experimental Studies in Animal Models of Parkinsons Disease.- 6-OHDA and MPTP Lesion Models.- Grafting of Embryonic Dopamine Neurons.- Human Embryonic Dopamine Neurons Grafted into the Rat Brain.- Grafting of Adrenal Medulla.- Clinical Studies in Patients with Parkinsons Disease.- Grafting of Adrenal Medulla.- Grafting of Embryonic Dopamine Neurons.- Research Strategies for the Development of a Transplantation Therapy in Parkinsons Disease.- Adrenal Medulla.- Embryonic Dopamine Neurons.- Other Approaches.- Conclusions.- References.- Transplantation in Huntingtons Disease: Experimental Basis and Clinical PerspectivelL